Biological synthesis of L-ascorbic acid in animal tissues: conversion of D-glucuronolactone and L-gulonolactone into L-ascorbic acid.
نویسندگان
چکیده
Simpson, S. A. & Tait, J. F. (1952). Endocrinology, 50, 150. Simpson, S. A. & Tait, J. F. (1953). Mem. Soc. Endocrin. 2,9. Southcott, C. M., Bandy, H. E., Newsom, S. E. & Darrach, M. (1956). Canad. J. Biochem. Phy8iol. 34, 913. Speirs, R. S. & Meyer, R. K. (1951). Endocrinology, 48, 316. Vogt, M. (1955). J. Physiol. 130, 601. Vogt, M. (1957). Ciba Foundation Colloq. Endocrin. 11, 193. Weichselbaum, T. E. & Margraf, H. W. (1955). J. clin. End,ocrin. Metab. 15, 970. Wilson, H. & Fairbanks, R. (1955). Arch. Biochem. Biophys. 54, 441. Zaffaroni, A. & Burton, R. B. (1951). J. biol. Chem. 193, 749.
منابع مشابه
Biological synthesis of L-ascorbic acid in animal tissues: conversion of L-gulonolactone into L-ascorbic acid.
The enzyme system catalysing the conversion of D-glucuronolactone and L-gulonolactone into Lascorbic acid in animal tissues has been previously reported to be entirely located in the microsomal fractions ofratand goat-liver homogenates (Burns, Peyser & Moltz, 1956; Chatterjee, Ghosh, Ghosh & Guha, 1957a, b; 1958a, b). The kidney tissue has been found to be the site of this conversion in amphibi...
متن کاملThe synthesis of L-ascorbic acid in the rat from D-glucuronolactone and L-gulonolactone.
Previous studies have shown that the intact carbon chain of glucose is utilized for the synthesis of L-ascorbic acid in the rat (l-3). Evidence for this precursor relationship came from experiments in which the administration of carbon land carbon 6-labeled glucose tracers resulted in the urinary excretion of n-ascorbic acid labeled predominantly in carbon 6 and carbon 1, respectively. Although...
متن کاملEffect of cyanide on the biosynthesis of ascorbic acid by an enzyme preparation from goat-liver tissue.
In exploring the mechanism of biosynthesis of ascorbic acid by the rat, King and his coworkers (Musulin, Tully, Longenecker & King, 1939; Longenecker, Musulin, Tully & King, 1939; Longenecker, Fricke & King, 1940) observed that rats treated with Chloretone (1:1:1-trichloro-2methylpropan-2-ol) excreted more ascorbic acid than did the controls. By employing Chloretonized rats and isotopically lab...
متن کاملBiosynthesis of Ascorbic Acid
hypophosphite for the conversion of D-glucuronolactone into L-ascorbic acid. 9. The presence of borate or Antabuse, each at mm-concentration, inhibits the conversion of Dglucuronolactone into L-ascorbic acid to about 50 %. 10. The optimum conditions for the action of the enzyme system have been studied. 11. The biosynthesized ascorbic acid has been identified by paper chromatography and by a bi...
متن کاملRegulation of Ascorbic Acid and of Xylulose Synthesis in Rat-liver Extracts. the Effect of Starvation on the Enzymes of the Glucuronic Acid Pathway.
1. The synthesis of ascorbic acid in rat-liver extracts is impaired during starvation, and more from glucuronolactone and glucuronate than from gulonate and gulonolactone. 2. The formation of xylulose from gulonate and from gulonolactone is greatly enhanced during starvation, whereas it is decreased from glucuronolactone and from glucuronate. 3. The activity of the enzymes of the glucuronic aci...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- The Biochemical journal
دوره 76 شماره
صفحات -
تاریخ انتشار 1960